PP257—Chlorogenic acid as potential anti-inflammatory analgesic agent

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Sinapic Acid Derivatives as Potential Anti-Inflammatory Agents: Synthesis and Biological Evaluation

Transcription factor NF-κB and relevant cytokines IL-6 and IL-8 play a pivotal role in thepathogenesis of inflammation. Sinapic acid is a natural product and was demonstrated to possessanti-inflammatory activity. In this paper, we synthesized a series of sinapic acid derivativesand evaluated their anti-inflammatory effects. The result suggested that all of the targetscompounds 7a-j inhibit NF-κ...

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Sinapic Acid Derivatives as Potential Anti-Inflammatory Agents: Synthesis and Biological Evaluation

Transcription factor NF-κB and relevant cytokines IL-6 and IL-8 play a pivotal role in thepathogenesis of inflammation. Sinapic acid is a natural product and was demonstrated to possessanti-inflammatory activity. In this paper, we synthesized a series of sinapic acid derivativesand evaluated their anti-inflammatory effects. The result suggested that all of the targetscompounds 7a-j inhibit NF-κ...

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Anti-Inflammatory and Analgesic Potency of Carboxyamidotriazole, a Tumorostatic Agent

Carboxyamidotriazole (CAI) is a calcium influx inhibitor that is undergoing clinical trials for the treatment of various human cancers following the identification of its antiproliferative and antimetastatic activities. The exact mechanism of its action is not clearly understood, and whether it has other functions besides the established antitumor activity has not been reported either. In the p...

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Toward a new anti-inflammatory and analgesic agent.

I a comparative study on normal and B1-receptor deficient (B1-KO) mice, Pesquero et al. (1) provide evidence in this issue of PNAS in favor of crucial roles played by the kinin B1 receptor in toxic shock, inflammation, and nociception. B1 receptors are generally silent or absent in healthy states and are induced or activated by pathological challenges. When they are absent, as in B1-KO mice, ti...

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[Anti-inflammatory and analgesic potency of carboxyamidotriazole, a tumoristatic agent].

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ژورنال

عنوان ژورنال: Clinical Therapeutics

سال: 2013

ISSN: 0149-2918

DOI: 10.1016/j.clinthera.2013.07.288